A soy protein long known to affect fertility can change how pregnancies start and progress in female mice treated with it as newbornsA soy protein, genistein, long known to affect fertility can change how pregnancies start and progress in female mice treated with it as newborns. The changes make it harder for fertilized eggs to implant and grow, possibly contributing to infertility. The effects were observed at levels comparable to those experienced by human infants feeding on soy formula.

What does it mean?
Genistein affects the uterus and the reproductive tract -- not the egg quality -- of the adult female mice that were treated with the soy phytoestrogen while in the womb. Fertilized embryos developing in the treated females did not attach and thrive as well as embryos in the control animals, even though eggs from genistein-treated females were as healthy as those from their unexposed counterparts.


The genistein-treated mice also lost more embryos early in their development. Embryo death means fewer births and higher rates of infertility.

Together, the results suggest that the uterus may be an important factor in genistein-induced infertility.

These findings pinpoint one actual cause of the observed infertility of early life exposure to genistein. They also highlight the need for a much better understanding of how soy infant formulas and other products fed to newborns and infants may influence a developing baby's reproductive life.

Egg quality was not affected by newborn genistein treatment. The immature eggs from genistein-treated mice developed normally and produced fertile female mice just like in the controls.

These findings add to a growing body of evidence that implies that newborns that eat soy-based products may be predisposed to lower reproductive success as adults.



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NEW YORK (Reuters Health) - A UK researcher has a new explanation for how the human race manages to keep a fairly even balance of males and females, despite massive deaths of young males in war and selective abortion of female fetuses in certain parts of the world.

Corry Gellatly, a research scientist at Newcastle University, proposes that there's a gene that determines whether a man will father more sons, more daughters, or equal numbers of each. When females are in short supply, they have a better chance of snagging a mate, and are thus more likely to pass the gene for fathering daughters on to their offspring. And when men are scarce, they have a better chance of mating and passing along the gene for having sons.

Full story: Evolutionary Biology, published online December 11, 2008.
http://www.reuters.com/article/healthNews/idUSTRE5001SV20090102?feedType=nl&feedName=ushealth1100


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Vitamin D deficiency may increase the likelihood of having a Caesarean sectionVitamin D deficiency may increase the likelihood of having a Caesarean section, a new study has found.

At the turn of the 20th century, according to background information in the report, deformed bones in the pelvis often led to a C-section, a problem that virtually disappeared with the vitamin D fortification of milk and other foods. But this study, published online Dec. 23 in The Journal of Clinical Endocrinology & Metabolism, suggests that vitamin D deficiency in pregnancy is still a problem.

The researchers studied 253 births at a Boston hospital from 2005 to 2007. After controlling for other variables, the scientists found that women with low blood levels of vitamin D were almost four times as likely to have an emergency C-section as those with normal levels. Vitamin D deficiency has been associated with muscle weakness and high blood pressure, which might help explain the finding.

Dr. Michael Holick, a professor of medicine at Boston University and the senior author of the study, offered straightforward advice for pregnant women. “Take a thousand-unit supplement of vitamin D, available at any pharmacy, on top of any prenatal vitamins you’re taking, so that you’re getting 1,400 units a day,” he said. “There is no downside to doing this.”


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NEW YORK (Reuters Health) - Canadian high school students may lack important knowledge about risk factors for infertility, survey findings suggest. For example, most students were unaware that some sexually transmitted infections can cause infertility.

"About 80 percent of students said they were familiar with the term infertility," Susan Quach, of Sunnybrook and Women's College Hospital Fertility Center in Toronto, told Reuters Health. But when asked more specific infertility-related questions, fewer students answered correctly, indicating a lack of knowledge that may increase their risk of infertility later in life, Quash said.

For example, more than 94 percent of the students did not know that sexually transmitted infections, such as chlamydia or gonorrhea can lead to infertility, Quash and co-investigator Dr. Clifford Librach at the University of Toronto report in the journal Fertility and Sterility.

The researchers asked 772 ethnically diverse high school students to complete a written questionnaire designed to determine their knowledge of and attitudes about infertility. The students were 17.5 years old, on average, and 49 percent were female.

A total of 608 students completed the questionnaire and, as noted, the vast majority did not know that chlamydia and gonorrhea can lead to infertility. About 25 percent thought fertility problems only occurred among women 40 years or older.

The researchers found that students from schools with low socioeconomic status more frequently gave incorrect answers and were significantly less aware of associations between sexually transmitted diseases and infertility.

Overall, about 73 percent of female and 67 percent of male respondents said protecting their fertility was important to them. Most also reported that their fertility was important to them. Fifty-five percent of the students said they were open to screening for sexually transmitted diseases as a means of protecting their fertility.

These findings highlight the importance of educating young people about modifiable risk factors for infertility, such as body fat, smoking, caffeine consumption, excessive exercise, drug use, and sexually transmitted infections, Quash and Librach note.

To assist the development of targeted and appropriate infertility prevention education, the investigators suggest that further infertility knowledge assessments should be conducted among students in rural or less ethnically diverse schools.

SOURCE: Fertility and Sterility, December 2008.
http://www.reuters.com/article/healthNews/idUSTRE4BS58L20081229?feedType=nl&feedName=ushealth1100


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 Pulling Down The Moon is offering several free classes for women who are thinking about becoming pregnantMany couples think twice about starting a family during tough economic times, but that doesn't mean the biological clock stops ticking. Pulling Down The Moon, specialists in holistic fertility care who work in partnership with medical doctors, is offering several free classes for women who are thinking about becoming pregnant.

Topics include what to eat to boost fertility; guidelines for weight loss and gain while trying to conceive; yoga for fertility, and massage techniques for couples to reduce stress and strengthen intimacy.

"We urge women to utilize these DIY tools and not allow a troubled economy to get in the way of fulfilling their family building dreams," said Tami Quinn, former fertility patient and co-founder of Pulling Down The Moon.

Centers are located in Arlington Heights, Naperville and Chicago. For a class schedule or to register, call (312) 321-0004 or visit fcionline.com.

Source: http://www.dailyherald.com/story/?id=260244&src=120




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